Localized mediastinal amyloidosis: A misnomer?
نویسندگان
چکیده
Amyloidosis is a disease related to abnormal protein folding and deposition of that abnormal protein between cells of the body in various tissues and organs, resulting in multiple clinical manifestations. We report a case of amyloidosis with atypical features, isolated to the mediastinum, in a 75-year-old male who presented with fatigue and shortness of breath. Amyloidosis that is isolated to the mediastinum without pulmonary parenchymal involvement is exceptionally rare. It has been hypothesized that localized mediastinal amyloidosis manifesting as amyloidomas is a distinct clinical subtype with a better prognosis than classic systemic amyloidosis. This paper describes the radiologic features of localized mediastinal amyloidosis (along with its pathologic correlation) and compares systemic and isolated disease.
منابع مشابه
Primary Localized Vesical Amyloidosis Mimicking Bladder Carcinoma: A Case Report
Amyloidosis of urinary bladder is a rare condition and may be primary or secondary in nature. A case of primary localized vesical amyloidosis (VA) in a 40-yr-old man is described confused with neoplasm by cystoscopic, urographic. Surgical specimens obtained by transurethral resection (TUR) were diagnostic and histologically revealed amyloid deposits in sub-epithelial stroma with chronic inflamm...
متن کاملOrgan limited amyloidosis with lymphadenopathy.
Hilar and mediastinal lymphadenopathy associated with localized pulmonary amyloid is very rare. We describe two cases of this unusual combination, one of endobronchial amyloid with adenopathy and the other of nodular parenchymal amyloid with hilar nodes. In both these cases the nodes contained calcification, and in the nodular parenchymal case in particular, this appearance is highly suggestive...
متن کاملPrimary amyloidosis presenting as an isolated mediastinal mass: diagnosis by fine needle biopsy.
Intrathoracic amyloidosis affecting the lungs or mediastinum is rare, and mediastinal lymphadenopathy in the absence of pulmonary involvement is even more rare. The case history is presented of a previously healthy man who developed nodular mediastinal amyloidosis without pulmonary involvement. Diagnosis was made by percutaneous fine needle biopsy.
متن کاملLocalized Thymic Amyloidosis Presenting with Myasthenia Gravis: Case Report
A mediastinal mass was incidentally found on chest radiography in a 46-yr-old woman who had had myasthenia gravis (MG) for 2 months. Computed tomography revealed a 4-cm in size, well-defined, and lobulating mass with nodular calcification that was located in the thymus. Microscopically, the mass consisted of diffuse amorphous eosinophilic materials. These deposits exhibited apple-green birefrin...
متن کامل